Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
DMRM marker 1 - SP110
Genotype / allele combination: GG - no risk allele at DMRM marker 1
This dog carries no risk allele at SP110 marker 1. At this marker, no additional SP110 modifier contribution to DM risk is detected beyond the SOD1 context.
Genotype / allele combination: GA - one risk allele at DMRM marker 1
This dog carries one risk allele at SP110 marker 1. If the dog also has an SOD1 risk genotype, this marker strengthens the modifier signal that can contribute to higher DM risk or earlier onset of signs.
Genotype / allele combination: AA - two risk alleles at DMRM marker 1
This dog carries two risk alleles at SP110 marker 1. Combined with an SOD1 risk genotype, this gives a stronger SP110 modifier pattern and is important for breeding selection and risk planning.
DMRM marker 2 - SP110
Genotype / allele combination: CC - no risk allele at DMRM marker 2
This dog carries no risk allele at SP110 marker 2. At this marker, no additional SP110 modifier contribution to DM risk is detected beyond the SOD1 context.
Genotype / allele combination: CT - one risk allele at DMRM marker 2
This dog carries one risk allele at SP110 marker 2. If the dog also has an SOD1 risk genotype, this marker strengthens the modifier signal that can contribute to higher DM risk or earlier onset of signs.
Genotype / allele combination: TT - two risk alleles at DMRM marker 2
This dog carries two risk alleles at SP110 marker 2. Combined with an SOD1 risk genotype, this gives a stronger SP110 modifier pattern and is important for breeding selection and risk planning.
DMRM marker 3 - SP110
Genotype / allele combination: AA - no risk allele at DMRM marker 3
This dog carries no risk allele at SP110 marker 3. At this marker, no additional SP110 modifier contribution to DM risk is detected beyond the SOD1 context.
Genotype / allele combination: AG - one risk allele at DMRM marker 3
This dog carries one risk allele at SP110 marker 3. If the dog also has an SOD1 risk genotype, this marker strengthens the modifier signal that can contribute to higher DM risk or earlier onset of signs.
Genotype / allele combination: GG - two risk alleles at DMRM marker 3
This dog carries two risk alleles at SP110 marker 3. Combined with an SOD1 risk genotype, this gives a stronger SP110 modifier pattern and is important for breeding selection and risk planning.
DMRM marker 4 - SP110
Genotype / allele combination: AA - no risk allele at DMRM marker 4
This dog carries no risk allele at SP110 marker 4. At this marker, no additional SP110 modifier contribution to DM risk is detected beyond the SOD1 context.
Genotype / allele combination: AG - one risk allele at DMRM marker 4
This dog carries one risk allele at SP110 marker 4. If the dog also has an SOD1 risk genotype, this marker strengthens the modifier signal that can contribute to higher DM risk or earlier onset of signs.
Genotype / allele combination: GG - two risk alleles at DMRM marker 4
This dog carries two risk alleles at SP110 marker 4. Combined with an SOD1 risk genotype, this gives a stronger SP110 modifier pattern and is important for breeding selection and risk planning.
DMRM marker 5 - SP110
Genotype / allele combination: AA - no risk allele at DMRM marker 5
This dog carries no risk allele at SP110 marker 5. At this marker, no additional SP110 modifier contribution to DM risk is detected beyond the SOD1 context.
Genotype / allele combination: AT - one risk allele at DMRM marker 5
This dog carries one risk allele at SP110 marker 5. If the dog also has an SOD1 risk genotype, this marker strengthens the modifier signal that can contribute to higher DM risk or earlier onset of signs.
Genotype / allele combination: TT - two risk alleles at DMRM marker 5
This dog carries two risk alleles at SP110 marker 5. Combined with an SOD1 risk genotype, this gives a stronger SP110 modifier pattern and is important for breeding selection and risk planning.
