CYP1A2 metabolism / Cognitive enhancer metabolizer (CYP1A2-related) - Dog

What does this test analyse?

This genetic test analyses the CYP1A2 c.1117C>T-variant in dogs. The trait is known as Metabolizer of a Cognitive Enhancer, CYP1A2 poor metabolizer, AC-3933 metabolism or CYP1A2-related metabolic status.

What does this condition mean?

CYP1A2 is a liver enzyme involved in processing certain chemical compounds. The tested nonsense variant reduces CYP1A2 function in dogs with two copies. Such dogs can process specific CYP1A2-dependent research or drug-like compounds differently from extensive metabolizers. This is a pharmacogenetic trait rather than a classic disease test.

Inheritance and result

The trait is interpreted as autosomal recessive. A dog with one copy is a carrier of the variant. A dog with two copies has the poor-metabolizer genotype for the tested CYP1A2 variant. The result therefore distinguishes normal metabolism, carrier status and poor-metabolizer status.

Practical value of this test

This test has practical value when breeders, owners, researchers or veterinarians want to understand CYP1A2 metabolism within a line. The result supports selection, family-line investigation and identification of dogs that may process certain compounds more slowly or differently.

• Supports breeding selection and risk management in lines where the variant occurs.
• Identifies hidden carriers before mating plans are made.
• Adds pharmacogenetic context for interpreting CYP1A2-dependent compounds.
• Helps organise research and health information in Beagle, Huntaway and New Zealand Heading Dog lines.

Result in brief

• Normal metabolism (C/C): the tested variant was not detected.
• Carrier (C/T): one copy was detected; the dog can pass the variant on.
• Poor metabolizer (T/T): two copies were detected; this genotype causes reduced CYP1A2 metabolism for the tested context.