Turnaround time
10 workdays
48.4
40
Test for the TYR c.230G>A variant explaining the rare Himalayan/OCA1 pigment pattern in Dachshunds.
Overview
This DNA test analyses the TYR variant c.230G>A that causes the OCA1 / Himalayan pigment pattern in the Dachshund. The trait is also known as Himalayan coat colour, acromelanism, oculocutaneous albinism type I, OCA1 and TYR-related pigment dilution.
TYR plays a key role in melanin pigment production. In the Himalayan/acromelanism pattern, pigment production is temperature-sensitive: the body can be very light to almost white, while cooler areas such as ears, muzzle, feet or tail can become darker. In young puppies the pattern can be subtle and become clearer with age.
Dogs with two copies can also have a pale nose and blue or lighter eyes. The final visible colour still depends on base colour and other coat-colour genes.
The trait is inherited as autosomal recessive. A dog with one copy is a carrier and normally does not show the Himalayan/OCA1 pattern. A dog with two copies develops the corresponding pigment pattern and passes the variant to all offspring.
Included subanalyses
This analysis includes the following subanalysis:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: Clear for the tested variant (GG)
The genotype is GG. This dog does not carry the tested TYR variant. For this subtest, this variant does not contribute to OCA- or Himalayan-related pigment dilution.
Genotype / allele combination: Carrier of the tested variant (GA)
The genotype is GA. This dog carries one copy of the tested TYR variant. One copy normally does not cause the pigment pattern, but the dog can pass the variant to offspring. This is important information for breeding combinations.
Genotype / allele combination: Two copies of the tested variant (AA)
The genotype is AA. This dog has two copies of the tested TYR variant. This genotype causes the corresponding Himalayan/acromelanisme pigment pattern with strongly reduced pigmentation of coat, skin, nose and/or eyes.
Sampling and submission guidelines





References