Turnaround time
10 workdays
48.4
40
DNA test for the CBD103 c.231_233del variant at the K locus, the dominant black K^B allele that can mask A-locus patterns.
Overview
This genetic test analyses the CBD103 variant c.231_233del at the canine K locus. The trait is known as K locus, dominant black, Dominant Black, K^B and beta-defensin 103-related black coat colour.
CBD103 influences pigment switching through interaction with MC1R. A dog with at least one K^B allele produces mainly dark pigment in many coat areas, so A-locus patterns such as sable, agouti or tan points are often masked. The visible base colour still depends on E locus, B locus, D locus, white spotting and other modifiers.
The K^B allele acts as autosomal dominant. A dog with K^y/K^y does not carry the tested dominant black deletion, K^B/K^y carries one copy and K^B/K^B carries two copies. Brindle is classically placed as k^br within the K-locus hierarchy, but this test focuses on the known CBD103 K^B deletion.
Included subanalyses
This analysis includes the following subanalysis:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: Dominant black K^B not detected (K^y/K^y)
This genotype contains no copy of the tested CBD103 K^B deletion. A-locus patterns such as sable, agouti or tan points can be visible when other colour genes allow them.
Genotype / allele combination: Dominant black - one copy (K^B/K^y)
This genotype contains one copy of the CBD103 K^B deletion. One copy is enough to cause dominant black and usually mask A-locus patterns, as long as E locus and other colour genes allow dark pigment.
Genotype / allele combination: Dominant black - two copies (K^B/K^B)
This genotype contains two copies of the CBD103 K^B deletion. The dog is genetically dominant black at this locus, will pass the K^B allele to all offspring and usually strongly masks A-locus patterns.
Sampling and submission guidelines





References