CLAD type III / Leukocyte adhesion deficiency type III (FERMT3-related) - Dog

What does this test detect?

This DNA test detects the FERMT3 insertion c.1349_1350insAAGACGGCTGCC that causes CLAD type III in dogs. The condition is also known as Canine Leukocyte Adhesion Deficiency type III, LAD3 or leukocyte adhesion deficiency type III.

What does this mean for the dog?

CLAD type III affects both white blood cells and platelets. Affected dogs may show severe susceptibility to infection, poor wound healing, fever, dental disease, lameness, skin infections and a bleeding tendency, especially after injury or procedures.

Inheritance and result

The trait is inherited as an autosomal recessive disorder. A dog with one copy is a carrier and can pass the variant on. Two copies cause CLAD type III.

Practical value of this test

• Breeders can identify carriers in relevant lines.
• The result helps avoid risk matings and provides clear selection information before puppies are born.
• In dogs with compatible clinical signs, the genetic result can add direction when assessing immune and bleeding problems.