Canine atopic dermatitis / cAD risk factor (SLAMF1-related) - Boxer / French Bulldog

What does this test analyse?

This DNA test analyses the SLAMF1 variant c.799+2T>C in Boxers and French Bulldogs. The condition is known as canine atopic dermatitis, cAD, atopy, atopic skin disease and inherited predisposition to allergic skin inflammation.

What does cAD mean?

Canine atopic dermatitis is a common chronic itchy skin disease with a complex inherited and environmental background. Typical signs include itching, scratching, licking, rubbing, redness, inflamed skin, hair loss, recurring ear inflammation and secondary skin infections. Signs often begin in young dogs and can be triggered by allergens such as house dust mites, pollen and mould spores.

• TT: the tested SLAMF1 risk variant was not detected.
• TC: one copy of the risk variant; this increases genetic predisposition to cAD in the studied breeds.
• CC: two copies of the risk variant; this represents a higher genetic risk profile for cAD.

Practical value of this test

The result helps breeders include inherited cAD predisposition more deliberately in selection decisions. In Boxers and French Bulldogs, this marker provides useful information about genetic risk profile, making it easier to choose matings and recognise dogs with increased predisposition early.