Turnaround time
10 workdays
72.6
60
DNA panel for 7 genetic markers that together contribute to larger or smaller body-size tendency in dogs.
Overview
This DNA test analyses 7 genetic markers that together contribute to body-size tendency in dogs. The trait is also known as Body Size, canine size, height, withers height, body weight and genetic size variation.
The panel includes markers at or near IGF1-AS, IGF1R, STC2, GHR, HMGA2 and SMAD2. These genes and loci are involved in growth signalling, skeletal development and regulation of body weight and height. They are interpreted together because body size is not a single-gene disorder, but a polygenic and multifactorial trait.
Each marker can carry an allele associated with smaller body size. For each marker, a dog can have zero, one or two small-size alleles. The combined score across all 7 markers gives a practical indication of genetic tendency toward larger, intermediate or smaller body size.
Across the studied dog breeds, these 7 markers explained approximately 46-52.5% of body-size variation. Among breeds with a standard weight below 41 kg, this increased to approximately 64.3% of weight variation. This gives the panel much more genetic context than a single marker alone.
This test is useful for breeders and owners when body size, height or weight matter for breeding goals, breed variation, crosses or planning within a line. The result makes genetic size tendency visible, also in young dogs or crosses where adult size cannot yet be judged reliably from appearance alone.
The result is not an exact prediction in centimetres or kilograms. Breed background, sex, nutrition, health, development and other genetic factors still influence the final adult size.
Included subanalyses
This analysis includes the following subanalyses:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: Larger-associated genotype (T/T)
For IGF1-AS rs22397284, no small-size alleles were detected. This marker does not increase the combined small-size score.
Genotype / allele combination: Intermediate genotype (T/C)
For IGF1-AS rs22397284, one small-size allele was detected. This marker counts as 1 point in the combined body-size score.
Genotype / allele combination: Smaller-associated genotype (C/C)
For IGF1-AS rs22397284, two small-size alleles were detected. This marker counts as 2 points in the combined body-size score.
Genotype / allele combination: Larger-associated genotype (G/G)
For IGF1R R204H, no small-size alleles were detected. This marker does not increase the combined small-size score.
Genotype / allele combination: Intermediate genotype (G/A)
For IGF1R R204H, one small-size allele was detected. This marker counts as 1 point in the combined body-size score.
Genotype / allele combination: Smaller-associated genotype (A/A)
For IGF1R R204H, two small-size alleles were detected. This marker counts as 2 points in the combined body-size score.
Genotype / allele combination: Larger-associated genotype (T/T)
For STC2 g.39182836T>A, no small-size alleles were detected. This marker does not increase the combined small-size score.
Genotype / allele combination: Intermediate genotype (T/A)
For STC2 g.39182836T>A, one small-size allele was detected. This marker counts as 1 point in the combined body-size score.
Genotype / allele combination: Smaller-associated genotype (A/A)
For STC2 g.39182836T>A, two small-size alleles were detected. This marker counts as 2 points in the combined body-size score.
Genotype / allele combination: Larger-associated genotype (G/G)
For GHR E191K / GHR(1), no small-size alleles were detected. This marker does not increase the combined small-size score.
Genotype / allele combination: Intermediate genotype (G/A)
For GHR E191K / GHR(1), one small-size allele was detected. This marker counts as 1 point in the combined body-size score.
Genotype / allele combination: Smaller-associated genotype (A/A)
For GHR E191K / GHR(1), two small-size alleles were detected. This marker counts as 2 points in the combined body-size score.
Genotype / allele combination: Larger-associated genotype (C/C)
For GHR P177L / GHR(2), no small-size alleles were detected. This marker does not increase the combined small-size score.
Genotype / allele combination: Intermediate genotype (C/T)
For GHR P177L / GHR(2), one small-size allele was detected. This marker counts as 1 point in the combined body-size score.
Genotype / allele combination: Smaller-associated genotype (T/T)
For GHR P177L / GHR(2), two small-size alleles were detected. This marker counts as 2 points in the combined body-size score.
Genotype / allele combination: Larger-associated genotype (G/G)
For HMGA2 g.8348804G>A, no small-size alleles were detected. This marker does not increase the combined small-size score.
Genotype / allele combination: Intermediate genotype (G/A)
For HMGA2 g.8348804G>A, one small-size allele was detected. This marker counts as 1 point in the combined body-size score.
Genotype / allele combination: Smaller-associated genotype (A/A)
For HMGA2 g.8348804G>A, two small-size alleles were detected. This marker counts as 2 points in the combined body-size score.
Genotype / allele combination: Larger-associated genotype (N/N)
For SMAD2 9.9 kb deletion, no small-size alleles were detected. This marker does not increase the combined small-size score.
Genotype / allele combination: Intermediate genotype (N/del)
For SMAD2 9.9 kb deletion, one small-size allele was detected. This marker counts as 1 point in the combined body-size score.
Genotype / allele combination: Smaller-associated genotype (del/del)
For SMAD2 9.9 kb deletion, two small-size alleles were detected. This marker counts as 2 points in the combined body-size score.
Sampling and submission guidelines






References