Bald thigh syndrome (IGFBP5 variant, sighthound type) - Dog

This analysis examines the IGFBP5 c.424C>T variant, a genetic variant associated with Bald thigh syndrome (BTS) in sighthounds. BTS is a condition in which hair loss is most commonly seen on the thighs, but it may also affect the lower legs, abdomen, or chest.

This result can help clarify whether your dog carries a genetic predisposition linked to this variant. It may be useful when interpreting hair loss, understanding your dog’s genetic profile, and making informed breeding decisions.

This variant is generally described as having autosomal recessive inheritance. Dogs with two copies of the variant have the highest genetic predisposition for BTS. Dogs with one copy are considered carriers and may pass the variant on to their offspring. Clinical expression can vary, so not every genetically predisposed dog will show the same degree of signs.

• Analysis of the IGFBP5 c.424C>T variant
• Relevant for BTS or hair loss fitting this pattern
• Useful for coat interpretation and breeding planning