Autoimmune lymphoproliferative syndrome / ALPS / FALPS (FASLG-related) - Cat

ALPS / FALPS in cats

This genetic test analyses the FASLG variant c.413_414insA that causes autoimmune lymphoproliferative syndrome in cats. The condition is also known as ALPS, FALPS or feline autoimmune lymphoproliferative syndrome, and has mainly been described in the British Shorthair.

Affected kittens usually develop severe immune dysregulation at a young age. Typical signs include markedly enlarged lymph nodes, an enlarged spleen, anaemia, lethargy, weight loss and rapid clinical decline.

Practical value of this test

• Clarifies whether a cat is clear, a carrier or genetically affected for the tested FASLG variant.
• Helps breeders avoid carrier-to-carrier matings and prevent affected kittens.
• Supports targeted selection in lines where ALPS/FALPS is known or suspected.

The condition follows an autosomal recessive mode of inheritance. Carriers are usually not ill because of this variant, but can pass it to offspring.